An Implantable Device Blocks Pain By Chilling Nerves Inside the Body
July 02, 2022

The implant prevents pain by cooling the nerves inside the body

Implants made of decaying material cool the nerves at 10 ° C, reduce the pain signals transmitted to the rat brain, and can be absorbed in the body over time.

However, This implant contains a flexible fiber that has small channels for the chemical to pass through.

Putting ice on the injury can alleviate the pain – and we can achieve the same result with implants that cool the nerve fibers inside the body.

The device can cool emotions up to 10 ° C, reducing pain signals sent to the brain, according to a prototype study in mice. It is made of decaying material, designed to be inserted after surgery and absorbed by the body as the pain of surgery subsides.

There is a great need for better ways to treat pain because opioids, a large class of drugs currently in use, can be addictive. Ice packs or cooling pads can help temporarily, but this may sound unpleasant and may damage the skin if used too long.

His team made a small piece of soft material that contained small holes for chemicals to flow. One end can be wrapped around the nerve fibers fiber cuff. The other end comes out of the skin and is attached to a small tap.

Nitrogen gas and a harmless liquid called perfluorobutane (PFP) are inserted through different channels in the line. The chemicals combine at the far end of the filament, causing the PFP to evaporate, giving a cooling effect.

PFP gas and nitrogen return through a third channel at the pump, where it is separated and PFP converts back into liquid. The device contains a temperature sensor so that the effect can be monitored and adjusted.

To test the device, it was placed near the sciatic nerve in the legs of three mice, and their paws were injured to make them more sensitive. Three weeks later, when each game was pressed using a sensitive measuring machine, it required seven times as much force for the animals to retract their leg when the cooling was turned on.

Six months later, the device had entered the body and there was no sign of emotional damage. The team now needs to continue examining implants in animals to understand how cold feelings can be – and for how long – without injury.

Many previous methods of pain management in mice have not been successful in humans, but it has been confirmed that cooling sensors prevent their function.

This type of implant can be very helpful for people with severe, chronic pain, as this is difficult to treat with opioids without leading to tolerance.

It is said that a permanent type of device can also be made, if necessary, by using durable materials. But the most natural use is about surgery that needs to happen anyway.

Catogries: News | Treatments

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